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Publications

Identify Symptom Patterns in People with HIV Disease

Symptoms guide disease management, and patients frequently report HIV-related symptoms, but HIV symptom patterns reported by patients have not been described inthe era of improved antiretroviral treatment. This study was an investigation of the prevalence and burden of symptoms in people living with HIV and attending an outpatient clinic. Even with improvements in HIV antiretroviral therapy, symptom prevalence and burden, independent of HIV-1 viral load and CD4+ T cell count, are high.

Connecting the Dots: Could Microbial Translocation Explain Commonly Reported Symptoms in HIV Disease?

Microbial translocation has been described as one of the contributing causes of inflammation and predictors of HIV disease progression. HIV-associated symptoms have been related to inflammatory markers and sCD14, a surrogate marker for microbial translocation, suggesting a plausible link between microbial translocation and symptom burden in HIV disease. Similar pathophysiological responses and symptoms have been reported in inflammatory bowel disease. In this article we presented a conceptual framework and rationale to investigate the link between microbial translocation and symptoms. The impact of inflammation on symptoms supports recommendations to reduce inflammation as part of HIV symptom management.

A Systematic Review of Probiotics as a Potential Intervention to Restore Gut Health in HIV Infection

Probiotics have been used in chronic illnesses exhibiting similar pathology seen in HIV gut dysfunction. In order to make recommentdations for their use to restore healing of the gut a review of the literature was performed and published. There is evidence that probiotics were supportive in modulating aspects of gut physiology, barrier integrity, and immune function. Probiotics could be considered as a supportive adjunct therapy and should be researched in persons with HIV Infection.

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